ABSTRACT
Objective: To evaluate the inclusion capacity and bactericidal efficiency of diallyl dimethyl ammonium chloride (PDADMAC) diluted in tetrahydrofuran (THF) upon inclusion in the medical grade silicone polymer structure. Material and Methods: It was diluted the PDADMAC in THF at the concentration of 4wt%. It was included in the silicon paste during its vulcanization process. The contact angle measurements were performed to evaluate whether the biocide inclusion into the silicon paste was successful. All samples were sterilized with gamma radiation at 25KGy-dosage prior to the microbiological tests. Microbiological testing strictly followed the Antibacterial products - Test for antibacterial activity and efficacy JIS Z 2801: 201010 and the used of specific bacteria, as Staphylococcus aureus ATCC 6538P and Escherichia coli ATCC 8739. Results: The results showed that PDADMAC, when dissolved in THF at 4wt%, displayed good incorporation in medical silicone and a broad-spectrum antibacterial response. The results of the tests using Escherichia coli ATCC 8739 and Staphylococcus aureus ATCC 6538P showed that the silicone with no biocide addition did not present antibacterial activity. In contrast, the experimental group plus 2 mL of PDADMAC would have an ideal antibacterial response. Conclusion: Medical grade silicone can be used as a material with antibacterial properties, since it has been able to keep PDADMAC compound attached to its structure, thus acquiring antimicrobial property.
Subject(s)
Silicone Elastomers/analysis , In Vitro Techniques/methods , Maxillofacial Prosthesis , Anti-Bacterial Agents/analysis , Silicone Elastomers , Brazil , Dental Materials , Methylenetetrahydrofolate Reductase (NADPH2)ABSTRACT
As próteses bucomaxilofaciais têm um importante papel na devolução da estética e de algumas funções para os pacientes. Suas boas condições são primordiais, para que possam exercer suas funções adequadamente e manter o local, onde estão inseridas, livre de infecções e inflamações. Portanto, as não formações de colônias e biofilmes bacterianos em materiais eleitos para confecção dessas próteses trarão benefícios aos pacientes reabilitados. Com esse propósito, o presente artigo verificou a eficiência bactericida dos biocidas policloreto de dialildimetilamônio (PDADMAC) e poliacrilamida catiônica (PAC) quando pincelado em resina acrílica termopolimerizável e silicone de grau médico. Os resultados mostraram que o biocida PDADMAC dissolvido em água obteve boa resposta antibacteriana, quando pincelado sobre ambos os materiais. Já o biocida PAC, entretando, mostrou eficiência antibacteriana apenas quando aplicado resina acrílica termopolimerizável... (AU)
The maxillofacial prosthesis have an important role in reestablishing esthetics and some of the patients functions. The prosthesis' condition is imperative to guarantee their appropriate function and keep the receptor site free of infections or inflammatory processes. Therefore, preventing the infection of the chosen material by bacterial colonies and biofilm can be hazardous to the patient's health. To investigate such problem, the present article evaluated the efficiency of two biocides: pol(diallyldimethylammonium chloride (PDADMAC) and polyacrylamide cationic (PAC). The biocides were applied over heat-cured acrylic resin or silicone. The results shows that the PDADMAC biocide dissolved in water had positive outcome when brushed over both materials. The PAC biocide had antibacterial efficiency only when brushed over the heat-cured acrylic resin... (AU)